Cuboid Syndrome
Other Names
- Subluxed cuboid
- Locked cuboid
- Dropped cuboid
- Cuboid fault syndrome
- Lateral plantar neuritis
- Peroneal cuboid syndrome
Background
- This page refers to a syndrome generally thought to be due to subluxation of the Cuboid
- Cuboid Fracture is discussed separately
History
- First case published in 1952 by B.S. Durall[1]
Epidemiology
- Epidemiology is poorly understood
- Found in 17% of ballet dancers with foot or ankle injuries[2]
- Found in 6.7% of patients with plantar flexion/ inversion ankle sprains[3]
Introduction



General
- Defined as a disruption or subluxation of the structural congruity of the calcaneocuboid portion of the midtarsal joint
- Poorly understood condition in both athletic and non-athletic populations
- Diagnostically challenging and easily misdiagnosed cause of lateral foot pain
- Treatment is generally non-surgical with good outcomes when treated appropriately
Etiology
- General
- Precise mechanism is not well understood
- Thought to arise from forceful eversion of the cuboid while the calcaneus is inverted, with resultant disruption of calcaneocuboid joint congruity
- Overuse
- In ballet dancers, from microtraumas to the ligamentous structures during maneuvers requiring maximum flexibility[3]
- Plantar flexion and inversion
- Noted as a complication of a plantar flexion and inversion ankle injury[2]
- Thought to represent the majority of cases
- Contributing factors
- Degree and direction of the force of the peroneus longus
- Position of the subtalar joint
- Overpronation of foot
Associated Conditions
- Lateral Ankle Sprain
- Jennings et al: 6.7% of patients with lateral ankle sprains also have cuboid syndrome[2]
- Tarsal Coalition
- Plantar Fasciopathy
Anatomy of the Cuboid
- Articulates with calcaneus (proximal), lateral cuneiform (medial), and metatarsals 4 and 5 (distal)
- Stabilizes calcaneocuboid joint, supports lateral column and functions as fulcrum during contraction of peroneus longus
- Peroneus Longus: tendon forms a sling around lateral, plantar aspects of the cuboid assists with calcaneocuboid stabilization
Anatomy of the Calcaneocuboid Joint
- Formed by the articulation of the calcaneus and cuboid
- Synovial, saddle-type articulation which is an important part of the chopart joint
Risk Factors
- Sports
- Ballet Dancers[3]
- Extrinsic
- Improperly constructed foot and ankle orthotics
- Uneven running terrain
- Faulty shoe construction
- Intrinsic
- History of Lateral Ankle Sprain
- Foot Pronation
Differential Diagnosis
Differential Diagnosis Foot Pain
- Fractures & Osseous Disease
- Traumatic/ Acute
- Stress Fractures
- Other Osseous
- Dislocations & Subluxations
- Muscle and Tendon Injuries
- Ligament Injuries
- Plantar Fasciopathy (Plantar Fasciitis)
- Turf Toe
- Plantar Plate Tear
- Spring Ligament Injury
- Neuropathies
- Mortons Neuroma
- Tarsal Tunnel Syndrome
- Joggers Foot (Medial Plantar Nerve)
- Baxters Neuropathy (Lateral Plantar Nerve)
- Arthropathies
- Hallux Rigidus (1st MTPJ OA)
- Gout
- Toenail
- Pediatrics
- Fifth Metatarsal Apophysitis (Iselin's Disease)
- Calcaneal Apophysitis (Sever's Disease)
- Freibergs Disease (Avascular Necrosis of the Metatarsal Head)
- Kohlers Disease (Avascular Necrosis of the Navicular)
Clinical Features


History
- They may have a history of an acute injury following an ankle sprain, or overuse following repetitive microtrauma
- Patients usually describe lateral foot pain at the site of the cuboid
- The pain may radiate into plantar medial arch, fourth metatarsal
- Pain is worse with weight bearing, during toe-off part of gait cycle
Physical Exam: Physical Exam Foot
- On inspection, swelling, redness and ecchymosis may be present
- If severe, a slight sulcus may be visible over the dorsum of the cuboid and a lump on the plantar surface[6]
- Subtle forefoot valgus may also be noted
- The patient will be tender directly over the cuboid
- There may also be tenderness along the peroneus longus tendo
- There may also be warmth, induration
- Range of motion is typically normal or slightly diminished
- Pain may be made worse with passive inversion and active, resisted plantar flexion and eversion
- Gait is antalgic
Special Tests
- Tarsometatarsal Glide Test
- Midtarsal Glide Test
- Midtarsal Adduction Test: stabilize ankle and subtalar joint, apply adduction force
- Midtarsal Supination Test: stabilize ankle and subtalar joint, apply supination force
- Dorsal Plantar Cuboid Shear Test: cuboid is passively translated dorsally or plantarally
Evaluation


Radiographs
- Standard Radiographs Foot
- Typically normal
- Disruption or subluxation is minor and not typically radiographically evident
CT
- Diagnostic value for cuboid syndrome is limited
- May be useful to exclude other diagnosis
MRI
- Diagnostic value for cuboid syndrome is limited
- May be useful to exclude other diagnosis
Classification
- Not applicable
Management

Nonoperative
- Indications
- Vast majority of cases
- Cuboid Manipulation
- Two techniques are described: the 'cuboid whip' and 'cuboid squeeze'
- Physical Therapy
- Emphasis on stretching the gastrocnemius, soleus, hamstring, and/or peroneus longus
- Strengthening the intrinsic and extrinsic foot muscles
- Useful to prevent recurrence
- Arch Taping with Kinesiology Tape
- Orthotic Padding
- Cuboid padding
- Immobilization if needed in short walking boot
Operative
- Needs to be updated
Rehab and Return to Play


Rehabilitation
- Cuboid Whip
- The clinician cups the dorsum of the patient’s forefoot
- Place thumbs on the plantomedial aspect of the cuboid.
- The atient’s knee is flexed 70° to 90°, the ankle is placed in 0° dorsiflexion
- With the patient’s leg relaxed, the clinician abruptly “whips” the foot into inversion and plantarflexion
- While delivering a low-amplitude, high-velocity thrust
- A “pop” or shift may be heard and/or felt by the clinician and/or patient
- Cuboid Squeeze
- Slowly stretche the ankle into maximal plantarflexion and the foot and toes into maximal flexion
- The cuboid is "squeezed" when the clinical feels the dorsal soft tissues relax
- The cuboid squeeze may not be appropriate for patients who have a coincident lateral ankle sprain
Return to Play/ Work
- General criteria[10]
- Resolution of pain and restoration of anatomical alignment and functional stability of the cuboid
- Full restoration of sport-specific skills and movement patterns
- Use of protective taping, padding, or orthoses as needed
Complications and Prognosis
Prognosis
- General[11]
- Prognosis is good when condition is recognized and treated appropriately
- Most patients experience rapid symptom resolution and return to full activity
- Physical therapy
- Patients have responded well to manipulation with the "cuboid whip" in small studies[12]
Complications
- Chronic lateral foot pain
- Persistent functional impairment
- Development of secondary conditions including:
- Peroneal Tendinopathy
- Cuboid Stress Fracture
- Calcaneocuboid Ligament Injury
See Also
Internal
External
- Sports Medicine Review Foot Pain: https://www.sportsmedreview.com/by-joint/foot/
References
- ↑ Durall, B. S. "Cuboid Syndrome." Journal of the American Podiatry Association. 1952;42:34-35
- ↑ 2.0 2.1 2.2 Jennings, Jason, and George J. Davies. "Treatment of cuboid syndrome secondary to lateral ankle sprains: a case series." Journal of orthopaedic & sports physical therapy 35.7 (2005): 409-415.
- ↑ 3.0 3.1 3.2 Marshall, Peter, and William G. Hamilton. "Cuboid subluxation in ballet dancers." The american journal of sports medicine 20.2 (1992): 169-175.
- ↑ Case courtesy of Craig Hacking, Radiopaedia.org, rID: 83347
- ↑ Angoules, Antonios G., et al. "Update on diagnosis and management of cuboid fractures." World journal of orthopedics 10.2 (2019): 71.
- ↑ Mooney, Maureen, and Lorrie Maffey-Ward. "Cuboid plantar and dorsal subluxations: assessment and treatment." Journal of Orthopaedic & Sports Physical Therapy 20.4 (1994): 220-226.
- ↑ Mazzotti, Antonio, et al. "Traumatic cuboid dislocation. the potential role of plantar ligaments integrity in facilitating reduction: a case report." JBJS Case Connector 11.2 (2021): e20.
- ↑ Sheahan, K., E. Pomeroy, and T. Bayer. "An isolated cuboid dislocation. A case report." International Journal of Surgery Case Reports 39 (2017): 1-4.
- ↑ 9.0 9.1 Durall, Chris J. "Examination and treatment of cuboid syndrome: a literature review." Sports Health 3.6 (2011): 514-519.
- ↑ Jennings, Jason, and George J. Davies. "Treatment of cuboid syndrome secondary to lateral ankle sprains: a case series." Journal of orthopaedic & sports physical therapy 35.7 (2005): 409-415.
- ↑ Marshall, Peter, and William G. Hamilton. "Cuboid subluxation in ballet dancers." The american journal of sports medicine 20.2 (1992): 169-175.
- ↑ Jennings J., Davies G.J. (2005) Treatment of cuboid syndrome secondary to lateral ankle sprains: a case series. Journal of Orthopedic and Sports Physical Therapy 35(7), 409-415
Created by:
John Kiel on 10 October 2021 10:19:50
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Last edited:
26 February 2026 15:00:28
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