Methylepitiostanol
Other Names
- Epistane
- 2α,3α-epithio-17α-methyletioallocholan-17β-ol
General
- Epistane is a synthetic anabolic-androgenic steroid (AAS), derivative of DHT that is frequently used for bodybuilding, but is not approved for medical use.[1]
Performance Enhancing Effects
- increased muscle mass, strength, and reduced body fat[2]
Medical Indications
- Not approved for any medical use.
Adverse Effects
- Common side effects include acne, gynecomastia, testicular atrophy, infertility, mood disturbances, hypertension, dyslipidemia
- Cholestasis, hepatitis, hepatic adenomas, and hepatocellular carcinoma
Mechanism
- Androgen receptor agonist
- Has a 2α,3α-epithio (epithioether) group on the A-ring that makes it resistant to aromatization[3]
WADA Considerations
- Banned by WADA
See Also
References
- ↑ Petrov PD, Fernández-Murga L, Conde I, et al. Epistane, an Anabolic Steroid Used for Recreational Purposes, Causes Cholestasis With Elevated Levels of Cholic Acid Conjugates, by Upregulating Bile Acid Synthesis (CYP8B1) and Cross-Talking With Nuclear Receptors in Human Hepatocytes. Arch Toxicol. 2020;94(2):589–607. doi:10.1007/s00204-019-02643-y
- ↑ Thevis M, Schänzer W. Synthetic Anabolic Agents: Steroids and Nonsteroidal Selective Androgen Receptor Modulators. Handb Exp Pharmacol. 2010;(195):99–126. doi:10.1007/978-3-540-79088-4_5
- ↑ Numazawa M, Handa W, Hasegawa C, Takahashi M. Structure–Activity Relationships of 2α-Substituted Androstenedione Analogs as Aromatase Inhibitors and Their Aromatization Reactions. J Steroid Biochem Mol Biol. 2005;97(4):353–9. doi:10.1016/j.jsbmb.2005.06.029