Common Peroneal Nerve Injection
Other Names
- Common Peroneal Nerve Injection
- CPN Injection
- Common Peroneal Nerve Block
Background

Key Points
- Needle: 25 gauge, 1.5 inch
- Transducer: high frequency, linear
- Recommend in-plane approach to avoid nerve injury
Anatomy of the Common Peroneal Nerve
- It is a branch of the sciatic nerve, bifurcating with the Tibial Nerve in the posterior mid thigh
- It branches off a the lateral sural cutaneous nerve before coursing into the popliteal fossa
- Just above the popliteal fossa, it bifurcates in the superficial peroneal nerve, deep peroneal nerve
Palpation Guidance vs Ultrasound Guidance
- There are no studies comparing palpation and ultrasound guidance
- This procedure can not be safely or reliably performed without ultrasound guidance
Indications
- Regional anesthesia for distal leg surgeries
- Possibly, for compressive neuropathy of the CPN
Contraindications
- Absolute
- Anaphylaxis to injectates
- Overlying cellulitis, skin lesion or systemic infection
- Relative
- Can be treated with less invasive means
- Hyperglycemia or poorly controlled diabetes
- Lack of symptom improvement with previous injection
Procedure



Equipment
- Sterile prep (i.e. chloraprep, chlorhexidine, iodine, etc)
- Gloves
- Needle: typically 21-25 gauge, 1.5 inch
- Syringe: 5-10 mL
- Gauze
- Ethyl Chloride
- Bandage
- Injectate
- Local anesthetic
- Corticosteroid
- Sterile probe cover
Ultrasound Findings
- Best visualized after it bifurcates off the sciatic nerve in short axis
- Typically at a depth of approximately 1-3 cm in the posterior thigh
Technique: Short Axis, In Plane
- Patient Position
- Lateral decubitus position
- Affected side up
- Transducer position
- Short axis to the knee joint
- Posterior and near the middle of the popliteal fossa
- Needle Approach/ Orientation
- In plane
- Target
- Perineureum of the common peroneal nerve
- Pearls and Pitfalls
- Identify and avoid the popliteal neurovascular bundle
- Short axis reduces risk of directly piercing the CPN
Aftercare
- No major restrictions in most cases
- Can augment with ice, NSAIDS
- Consider Knee Compression Sleeve to reduce re-accumulation/ swelling
Complications
- Infection
- Damage to surrounding tissue
See Also
Internal
References
- ↑ Waxman S. Clinical Neuroanatomy. 26th ed. New York: McGraw-Hill Medical; 2009: figure C-16.)
- ↑ Ting, Paul H., John G. Antonakakis, and David C. Scalzo. "Ultrasound-guided common peroneal nerve block at the level of the fibular head." Journal of Clinical Anesthesia 24.2 (2012): 145-147.
- ↑ Image courtesy of radiologykey.com
- ↑ Malanga, Gerard A., and Kenneth R. Mautner. "Atlas of ultrasound-guided musculoskeletal injections." (No Title) (2014).
Created by:
John Kiel on 10 April 2025 13:30:30
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Last edited:
10 April 2025 14:37:27
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