Saphenous Nerve Entrapment
Other Names
- Saphenous Neuropathy
- Surfer's neuropathy
- Entrapment Neuropathy of the Infrapatellar Branch of the Saphenous Nerve
- Infrapatellar Saphenous Neuralgia
- Saphenous neuroma
- Saphenous neuropathic pain syndrome
- Gonalgia Paresthetica
Background
- This page refers to neuropathies of the Saphenous Nerve
History
Epidemiology
- Incidence is not well documented in the literature
Pathophysiology

- Misdiagnosis
- Easily missed and overlooked by physicians
- Often misdiagnosed as more common causes of medial knee pain (meniscus, MCL, PFPS, knee OA, pes anserine pain)
- Often fail other common treatment modalities due to misdaignosis
Etiology
- Entrapment at the medial knee[2]
- Courses deep to Sartorius traveling laterally to medially as it descends the thigh
- Nerve exits through adductor (Hunter's) canal at medial knee, then travels distally into the calf
- Iatrogenic during orthopedic surgery
- Other causes
- Prolonged periods of kneeling
- Case reports following
- Blunt trauma to medial thigh[8]
Pathoanatomy
- Saphenous Nerve
- Sensory branch of the Femoral Nerve
- Distribution is medial leg
- Medial femoral condyle: divides into infrapatellar branch, terminal saphenous branch
- Infrapatellar branch: innervates the skin below the patella, anterior inferior knee capsule
- Terminal saphenous branch: innervates the skin of the anterior and medial lower leg
Risk Factors
- Sports
- Surfing
Differential Diagnosis
- Fractures
- Dislocations & Subluxations
- Patellar Dislocation (and subluxation)
- Knee Dislocation
- Proximal Tibiofibular Joint Dislocation
- Muscle and Tendon Injuries
- Ligament Pathology
- Arthropathies
- Bursopathies
- Patellofemoral Pain Syndrome (PFPS)/ Anterior Knee Pain)
- Neuropathies
- Other
- Bakers Cyst (Popliteal Cyst)
- Patellar Contusion
- Pellegrini Stieda Syndrome
- Parameniscal Cyst
- Pediatric Considerations
- Patellar Apophysitis (Sinding-Larsen-Johnansson Disease)
- Patellar Pole Avulsion Fracture
- Tibial Tubercle Avulsion Fracture
- Tibial Tuberosity Apophysitis (Osgood Schalatters Disease)
- Proximal Tibial Metaphyseal Fracture
- Proximal Tibial Physeal Injury
Clinical Features
- History
- The patient will complain of vague medial knee pain
- Can radiate down medial aspect of leg into the foot
- Pain may or may not be worse with movement
- Pain may be described as dull, achy, burning
- Worse with stairs, sitting, prolonged walking[9]
- Physical Exam: Physical Exam Knee
- Medial tibial fossa may demonstrate swelling
- May be tender over medial tibial plateau or fossa, medial patellar facet, retinaculum
- Diminished sensation to light touch of anteromedial knee
- Hypesthesia or allodynia may be present
- Knee flexion and abduction may increase pain and give false positive to meniscus etiology
- Special Tests
- Tinels Test: percussion over the adductor canal or medial tibial fossa may replicate pain
- Adductor canal: approximately 7 cm proximal, 10 cm medial to superior pole of patella
- Infrapatellar branch: 3-5 cm medial to the medial mid-patella border with knee in extension
- Tinels Test: percussion over the adductor canal or medial tibial fossa may replicate pain
Evaluation

Radiographs
- Standard Radiographs Knee
- Should be obtained
- Typically normal or expected postoperative findings
EMG/NCS
- Described in literature
- Questionable utility
- Likely less valuable than a diagnostic injection
Diagnostic Nerve Block
- Description for infrapatellar branch
- Knee is in flexion
- Isolate the point of maximal tenderness in the medial tibial fossa
- Needle enters from below, directed towards tibial tubercle and advanced to bone
- Consider adding corticosteroid to injection
- Use small volumes (1-2 mL) to avoid local anesthetic infiltrating other areas and avoiding confounding
- Consider using ultrasound guidance
Classification
- Not applicable
Management
Nonoperative
- Indications
- First line therapy in virtually all cases
- NSAIDS
- Other medications to consider
- Heat Therapy
- Ice Therapy
- Activity modification
- Physical Therapy
- Consider
- Myofascial Release
- Vibration therapy
- Nerve Glide Exercises (nerve flossing)
- Transfrictional massage
- Prevention
- Use of Knee Pads if associated with kneeling activities or occupation
Procedures
- Corticosteroid Injection
- Can be used diagnostically, therapeutically
- Often transient relief
- Pulsed Radiofrequency Ablation
- Has been described[10]
- Cryoneuroablation
- Should also be considered[11]
- Ultrasound guided Hydrodissection
- With ultrasound guidance, can be performed at the site of compression
Operative
- Indications
- Failure of conservative measures
- Technique
- Surgical decompression[12]
- Neurolysis
- Neurectomy
Rehab and Return to Play
Rehabilitation
- Needs to be updated
Return to Play/ Work
- Needs to be updated
Complications and Prognosis
Prognosis
- Unknown
Complications
- Chronic knee pain
See Also
- Internal
- External
- Sports Medicine Review Knee Pain: https://www.sportsmedreview.com/by-joint/knee/
References
- ↑ 1.0 1.1 Trescot, Andrea M., Michael N. Brown, and Helen W. Karl. "Infrapatellar saphenous neuralgia-diagnosis and treatment." Pain physician 16.3 (2013): E315-24.
- ↑ Kalenak, Alexander. "Saphenous nerve entrapment." Operative Techniques in Sports Medicine 4.1 (1996): 40-45.
- ↑ Dellon AL, Mont MA, Krackow KA, Hungerford DS. Partial denervation for persistent neuroma pain after total knee arthroplasty. Clin Orthop Relat Res 1995; 316:145-150.
- ↑ Papastergiou SG, Voulgaropoulos H, Mikalef P, Ziogas E, Pappis G, Giannakopoulos I. Injuries to the infrapatellar branch(es) of the saphenous nerve in anterior cruciate ligament reconstruction with four-strand hamstring tendon autograft: Vertical versus horizontal incision for harvest. Knee Surg Sports Traumatol Arthrosc 2006; 14:789-793.
- ↑ Kartus J, Movin T, Karlsson J. Donor-site morbidity and anterior knee problems after anterior cruciate ligament reconstruction using autografts. Arthroscopy 2001; 17:971-980
- ↑ Mochida H, Kikuchi S. Injury to infrapatellar branch of saphenous nerve in arthroscopic knee surgery. Clin Orthop Relat Res Nov 1995; 320:88-94.
- ↑ Leliveld MS, Verhofstad MHJ. Injury to the infrapatellar branch of the saphenous nerve, a possible cause for anterior knee pain after tibial nailing? Injury 2012; 43:779-783.
- ↑ Herman, Daniel C., and Kevin R. Vincent. "Saphenous neuropathy—a masquerading cause of anteromedial knee pain." Current sports medicine reports 17.6 (2018): 177.
- ↑ Morganti CM, McFarland EG, Cosgarea AJ. Saphenous neuritis: a poorly understood cause of medial knee pain. J. Am. Acad. Orthop. Surg. 2002; 10:130–7.
- ↑ Akbas M, Luleci N, Dere K, Luleci E, Ozdemir U, Toman H. Efficacy of pulsed radiofrequency treatment on the saphenous nerve in patients with chronic knee pain. J Back Musculoskelet Rehabil 2011; 24:77-82.
- ↑ Trescot A. Cryoanalgesia in interventional pain management. Pain Physician 2003; 6:345-360.
- ↑ Lippitt, A. B. "Neuropathy of the saphenous nerve as a cause of knee pain." Bulletin (Hospital for Joint Diseases (New York, NY)) 52.2 (1993): 31-33.
Created by:
John Kiel on 15 August 2021 22:10:24
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Last edited:
4 October 2022 15:56:10
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