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Nerve Anatomy

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Peripheral Nerves

Illustration of the cervical plexus[1]
Anatomy of brachial plexus[2]
Dermatomes of the upper extremity
Illustration of the lumbosacral plexus[3]

Occipital Nerves

Cervical Plexus

Upper Extremity: Brachial Plexus

Thoracic

Lower Extremity: Lumbosacral Plexus


Spinal Cord

Anatomy of the spinal cord[4]

General

  • Tubular bundle of nervous tissue extending from the brainstem to the lumbar vertebrae
  • When combined with the brain, forms the central nervous system

Gross Anatomy

  • Cylindrical structure, grey-white in color
  • Arises as a continuation of the medulla (inferior part of the brain stem))
  • Travels inferiorly within the vertebral canal
  • Protected/ surrounded by meninges which contain cerebrospinal fluid
  • At approximately L2, the cord tapers off forming conus medullaris
  • The spinal nerves bundled together at the end of the conus are known as cauda equina
  • Cervical enlargement: located at C4-T1, represents origin of brachial plexus
  • Lumbar enlargement: located at T11-L1, represents origin of lumbosacral plexus

Cranial Nerves

Anatomy of cranial nerves. a Pathways of cranial nerves to various innervated tissues of the body[5]
  • Olfactory nerve (I)
  • Optic nerve (II)
  • Oculomotor nerve (III)
  • Trochlear nerve (IV)
  • Trigeminal nerve (V)
  • Abducens nerve (VI)
  • Facial nerve (VII)
  • Vestibulocochlear nerve (VIII)
  • Glossopharyngeal nerve (IX)
  • Vagus nerve (X)
  • Accessory nerve (XI)
  • Hypoglossal nerve (XII)

Brain

Anatomic cross section of human brain in sagittal plane[6]

General

  • Central organ of the nervous system
  • Combined with spinal cord, comprises the central nervous system
  • Brain consists of cerebrum, brainstem, cerebellum
  • Controls the activities of the body
  • Processes, receives and integrate the signals it receives from the sensory nervous system
  • Delegates instructions to the rest of the body

Cerebrum

  • Largest part of the human brain, divided into two hemispheres
  • Inner later of white matter, outer layer of grey matter
  • Divided into four lobes (frontal, parietal, temporal, occipital)
  • Frontal: executive functions including self control, planning, reasoning, abstract thought
  • Occipital: vision
  • Left cerebrum specializes in language
  • Right cerebrum specializes in visual-spatial ability
  • Hemispheres connected by commissural nerve tracts such as the corpus callosum

Brainstem

  • Lies beneath the cerebrum in the back part of the skull
  • Consists of midbrain, pons, medulla oblongata
  • 10/12 cranial nerves originate directly from the brainstem

Other

  • Cerebrum contains the 4 ventricles where CSF is produced

Cellular Anatomy

Anatomy and physiology of a nerve[7]

Terminology

  • Nerve: enclosed, cable-like bundle of nerve fibers in the peripheral nervous system
  • Neuron: single individual nerve, considered the basic unit of the nervous system
  • Axon: extension of an individual neuron
  • Schwann cell: coats the axon in myelin
  • Fascicle: bundle of axons
  • Endoneurium: layer of connective tissue that surrounds each axon
  • Perineurium: layer of connective tissue that surrounds each fasciclee
  • Epineurium: layer of connective tissue that wraps around the entire nerve
  • Nerves are either classified as sensory or motor

Action

  • Provides an electrochemical impulse called an action potential
  • This is transmitted along the axon to peripheral organs or to the central nervous system

See Also


References

  1. Case courtesy of Craig Hacking, Radiopaedia.org, rID: 37804
  2. Grahn-Shahar, Petra. "Improving Shoulder Function in Brachial Plexus Birth Injury." (2021).
  3. Liyew, Worku Abie. "Clinical presentations of lumbar disc degeneration and lumbosacral nerve lesions." International journal of rheumatology 2020.1 (2020): 2919625.
  4. II, Phillip A. Swanson, and Dorian B. McGavern. "Portals of viral entry into the central nervous system." The blood-brain barrier in health and disease, Volume two: Pathophysiology and pathology 23 (2015).
  5. Sultana, Sharmin, et al. "Medial axis segmentation of cranial nerves using shape statistics-aware discrete deformable models." International Journal of Computer Assisted Radiology and Surgery 14 (2019): 1955-1967.
  6. Prakash, Kovvali Bhanu, and Appidi Adi Sesha Reddy. "Neuromarketing: The New Dawn and Disruption in Marketing." The science of emotional intelligence (2021): 103.
  7. Santana, N., et al. "An update on oral peripheral nerve sheath tumors." Journal of Oral and Maxillofacial Pathology 26.4 (2022): 541-552.
Created by:
John Kiel on 13 March 2025 20:54:59
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Last edited:
17 September 2025 19:33:33
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